Anesthetized Pulmonary Mechanics
Use anesthetized pulmonary mechanics to directly measure lung resistance and dynamic compliance on sedated subjects. The subjects may be ventilated or spontaneously-breathing.
To measure resistance and compliance, a system must collect two signals: flow and pressure.
The flow signal may be collected using a plethysmograph, an in-line pneumotachograph, or a thoracic belt.
For the pressure signal, the ventilated subject is intubated or fitted with a mask. An esophageal tube is used for spontaneously-breathing subjects and may be used for a reference pressure with ventilated subjects.
The flow and pressure signals are processed together to determine resistance and compliance using a software analyzer provided in BioSystem XA software. Choose one or more of these analyzers:
- RC Covariance
- RC Isovolumetric
- VentRC, for analysis of inspiration only
- vxRC, offering preconfiguration by species and dynamic adjustment
Reported Parameters
- Resistance
- Compliance
- Maximum mouth pressure deflection
- Maximum pleural pressure deflection
- Breath rate
- Tidal volume
- Total volume breathed
- Peak inspiratory flow
- Peak expiratory flow
- Inspiratory time
- Expiratory time
- End inspiratory pause
- End expiratory pause
- Others
This analysis is suitable for a wide range of species; the approach will vary depending on size and study requirements.
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